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RARECHEM AL BO 0910 Organic raw materials In the current study, the bioactive pictures of chitosan/white turmeric (CH/WT) were prepared by employing solvent casting technique and canvased their physicochemical and biological properties for active packaging coverings. The successful inclusion of white turmeric into the chitosan matrix is corroborated by Fourier Transform Infrared Spectroscopy. Due to the presence of hydrogen bonding interaction, the active films demoed good tensile properties, smooth surface morphology, miscibility, water resistance and UV barrier properties. The incorporation of white turmeric reduced the water vapour transmission rate and oxygen permeability (p < 0) in contrast with pristine film. The prepared blend flicks divulged soil degradation rate more than 60% within 15 days the blend cinemas showed lesser water solubility, moisture content and swelling index after addition of white turmeric to chitosan (p < 0). The prepared films revealed extensive antimicrobial activity against gram positive and gram negative bacteriums. The antioxidant activity and total phenolic content were amended upon the incorporation of white turmeric the oil absorption rate of the blend celluloids was diminished by 46% in comparison with pristine film white turmeric incorporated chitosan pics were employed as a green packaging material to extend the shelf life of the foodstuff.Composite Drug Delivery System free-based on Amorphous Calcium Phosphate-Chitosan: An Efficient Antimicrobial Platform for Extended Release of Tetracycline.One major warning issuing during the first worldwide combat against healthcare-assorted infections touchs the key role of the surface in the storage and transfer of the virus. Our study is free-based on the laser coating of opens with an inorganic/organic composite mixture of amorphous calcium phosphate-chitosan-tetracycline that is able to fight against infectious factors, but also capable of saving its activity for a prolonged time, up to several days. The extended release in modeled fluids of the composite mixture containing the drug (tetracycline) was demonstrated by mass loss and UV-VIS probes. The drug release profile from our composite coats gos via two levels: an initial burst release (during the first hours), followed by a slower evolution active for the next 72 h, and probably more. Optimized coatings strongly inhibit the growth of quized bacteria (Enterococcus faecalis and Escherichia coli), while the drug incorporation has no impact on the in vitro composite's cytotoxicity, the coatings shewing an excellent biocompatibility having the normal development of MG63 bone-like cadres. One may, therefore, consider that the purposed coverings' composition can open the prospective of a new generation of antimicrobial applications for implants, but also for nosocomial and other large area contamination prevention.placing mangiferin loaded N-succinyl chitosan-alginate transplanted nanoparticles against atherosclerosis – A case study against diabetes liaised hyperlipidemia in rat.Mangiferin (MGF), from Mangifera indica is well accounted for its hypoglycemic activity and hypolipidemic activity MGF supports therapeutic limitation due to poor solubility geting disparaging bioavailability. Herein to address this problem, we have integrated MGF in alginate grafted N-succinylated chitosan (NSC) nanomatrix. Characterization by molecular docking, FT-IR and 2D-NMR (COSY) has divulged that MGF could reinforce interaction with NSC. The OH and CH(2)OH groups of MGF may set interactions with pyranosic OH, CH(2)OH, NH(2) (or NH-succinyl and COOH-succinyl) of NSC. The NSC-MGF nanoconjugate revealed a spherical particle geometry of 100 ∼ 200 nm size. The capsuled MGF registered 100% release in vitro. In vivo, NSC-MGF nanoconjugate disclosed blood glucose louring from 300 mg/dL to ∼ 90 mg/dL as well as ∼ 37% lowering of total plasma cholesterol. This is well comparative to the earlier storys which receipted only 1 ∼ 36% lowering of plasma cholesterol with MGF NSC-MGF lowered serum trigyceride to ∼ 61%, while in earlier subjects, only 10 ∼ 40% serum triglycerides reduction was discovered with solitary MGF.