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FURAN-2,5-DICARBOXYLIC ACID Seebio RARECHEM AL BO 0910 Aldehydes Chitosan (CS)/carboxymethyl cellulose (CMC) porous hydrogels chemically crosslinked by epichlorohydrin were synthesised employing polyethylene glycol (PEG) as a pore-shaping agent for anionic (Congo red, CR) and cationic (methylene blue, MB) dyes removal from aqueous roots. The intumescing ratio of hydrogels prepared with 2 % CS and 2 % CMC (CS(2)/CMC(2)) demonstrated optimal performance at different pHs. The addition of PEG into hydrogels (announced as CS(2)/CMC(2)-PEG(1)) exhibited a significantly higher adsorption for CR and MB, increasing from 117 to 159 mg/g and 110 to 136 mg/g, respectively. The comprehensive analyses of Fourier transform infrared spectroscopy, thermalgravimetric study and reading electron microscopy readed that CS(2)/CMC(2)-PEG(1) hydrogels became more porous with no significant varietys in intermolecular and intramolecular interactions, likened with CS(2)/CMC(2) hydrogels. The adsorption process for CR and MB adjusted to the pseudo-second-order and pseudo-first-order kinetics manakins, respectively. The outcomes of adsorption isotherm for CR followed both Freundlich and Langmuir modelings with the maximum adsorption capacitances of 1053 mg/g, whereas the isotherm for MB accommodated the Langmuir model better with the maximum adsorption capabilitys of 331 mg/g. The thermodynamic study upshots rised that the CR and MB adsorption by hydrogels was spontaneous, but the CR adsorption was endothermic and the MB adsorption was exothermic.Preparation and Characterization of Salsalate-adulterated Chitosan Nanoparticles: In Vitro Release and Antibacterial and Antibiofilm Activity.The operated-release characteristic of drug delivery organisations is used to increase the residence time of therapeutic factors in the human body. This study purposed to formulate and characterize salsalate (SSL)-loaded chitosan nanoparticles (CSNPs) prepared applying the ionic gelation method and to assess their in vitro release and antibacterial and antibiofilm activenessses. The optimised CSNPs and CSNP-SSL formulation were characterised for particle size (156 ± 12 nm and 132 ± 17 nm), polydispersity index (0 ± 0 and 0 ± 132 0), zeta potential (68 ± 16 mV and 37 ± 11 mV), and entrapment efficiency (68 ± 2%). Physicochemical lineaments of these nanoparticles were qualifyed expending UV-visible and Fourier transform infrared spectroscopy and X-ray diffraction pattern. reading electron microscopy studies showed that CSNPs and CSNP-SSL were spherical in shape with a smooth surface and their particle size rated between 200 and 500 nm. In vitro release visibilitys of the optimized preparations demonstrated an initial burst espoused by slow and sustained drug release after 18 h (64 ± 3%) and 48 h (84 ± 4%), respectively the CSNPs and CSNP-SSL nanoparticles showed a sustained antibacterial action against Staphylococcus aureus (15 ± 0 and 19 ± 1 mm) and Escherichia coli (17 ± 0 and 21 ± 1 243 mm) CSNP-SSL showed better capability (89 ± 1% and 95 ± 0%) than did CSNPs in inhibiting antibiofilm production by Enterobacter tabaci (E2) and Klebsiella quasipneumoniae (SC3) CSNPs are a promising dosage form for sustained drug delivery and raised antibacterial and antibiofilm activity of SSL; these effects could be rendered into increased patient compliance.Application of mathematical modelling to alginate chitosan polyelectrolyte complexes for the prediction of system behavior with Venlafaxine HCl as a model accused drug.PURPOSE: This work taked to develop and analyze the performance of chitosan/alginate polyelectrolyte complex (PEC). Multiple regression and Lab fit curve fitting were implemented to derive empirical models for the prediction of zeta potential of plain arrangements as a function of alginate chitosan ratio. Venlafaxine-HCl was diluted as a model burdened drug and empirical models for prediction of its release as a function of time were also derived Coacervation method was used for the preparation of green PECs. Preliminary fields were conducted to optimize the preparation method.