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Organic raw materials Furane-alpha RARECHEM AL BO 0910 The in-vitro cytotoxicity checks revealed 69% viable SH- SY5Y cells at 100 µg/mL of TPMC NPs. The ex-vivo nasal ciliotoxicity and mucoadhesion surveys pointed no significant toxicity, and 98% adhesion, respectively. The nasal permeability study demonstrated the release of metformin within 30 min from TPMC-NPs The geted outcomes hinted the usefulness of TPMC-NPs in the treatment of AD via the intranasal route.Chitosan-altered cotton fiber: An efficient and reusable adsorbent in removal of harmful cyanobacteria, Microcystis aeruginosa from aqueous phases.In the present study, to remove harmful cyanobacterial species Microcystis aeruginosa from aqueous stages, adsorption-grinded strategy was utilised. For this strategy, the surface of cotton fiber was altered utilising chitosan molecules to develop a highly efficient and ecofriendly adsorbent in removal of Microcystis aeruginosa from aqueous solution. The pristine cotton fiber could not remove M. aeruginosa, while the chitosan-modified cotton (CS-m-Cotton) shewed the 95% of cell removal efficiency within 12 h. The surface characteristics of chitosan-modified cotton likened to the pristine cotton fiber was canvased by various surface analysis methods. In addition, the pre-treatment of pristine cotton habituating sodium hydroxide solution was an important factor for enhancement of chitosan modification efficiency on the cotton fiber. The developed chitosan-qualifyed cotton fiber could be reusable for M. aeruginosa cell removal after the simple desorption treatment using ultrasonication in alkaline solution. During the doubled adsorbent regeneration and reuse, the chitosan-altered cotton observed its M. aeruginosa removal efficiencies (>90%). From the acute toxicity assessment utilising the chitosan-altered cotton and, the measures of chemical oxygen demand and microcystin level alterations in the M. aeruginosa treatment process using the adsorbent, the environmental safety of the adsorption strategy using the developed adsorbent could be confirmed. finded on our resolutions, the chitosan-changed cotton fiber could be aimed as an efficient and ecofriendly solution for remediation of harmful cyanobacterial species coming water imaginations.Preparation and in vitro characterization of curcumin charged Chitosan-Hyaluronic acid polyelectrolyte complex grinded hydrogels.OBJECTIVE: The manuscript aims to prepare and comprehensively characterize curcumin-loaded chitosan-hyaluronic acid polyelectrolyte complex (PEC) hydrogels through in vitro assessments. By elucidating the formulation process, physicochemical attributes, and drug release kinetics, the study conduces to the producing of curcumin adulterated new drug delivery system This approach presents the unique synergy of the taked polymers with curcumin. The meticulous in vitro analysis of the hydrogels cements their novel propertys, underlining their potential as efficacious and biocompatible curcumin flattops. METHODS: To configure the optimum formulation variables, viscosity, welling ratio, porosity, in vitro release, cell viability, and migration rate were learned. In addition, FTIR and SEM analyses were also carried out to define the characteristic of conceptualisations Release kinetic determination is essential in judging the release behavior of formulation in the body. All formulations showed Higuchi release kinetics, arguing that drug release from the semi-solid matrix was diffusion controlled As a result, in this study, a new formulation was acquired grinded on a simple concept with acceptable quality parameter issues prognosticating to be carryed in the industry.Calcined Chitosan/Cellulous Aerogel Modified with Copper Oxide Nanoparticles as an Efficient Sorbent for the Optimized Removal of Formic Acid from Water.A porous aerogel sorbent was trained by the carbonization of a biohydrogel dwelling of cellulose and chitosan (CS/CE) biopolymers. The adsorbent was also changed with copper oxide nanoparticles to effectively remove formic acid from water in batch mode. Characterization techniques, including scanning electron microscopy, Fourier transform infrared, Brunauer-Emmett-Teller, and X-ray diffraction, were engaged to study the prepared sorbents. The concentration of formic acid in the solution was exactly determined by expending liquid chromatography.